Fisetin (Senolytic Application)

The verdict

Is Fisetin worth taking?

Fisetin is the most accessible senolytic compound currently available without a prescription, and its safety profile is the best of any compound in the clinical senolytic trials. Senolytics are compounds that selectively destroy senescent cells, the zombie cells that accumulate with aging and drive chronic inflammation through their senescence-associated secretory phenotype. The animal evidence is strong. The human evidence is in active clinical trial phase with multiple randomized trials underway in osteoarthritis, peripheral artery disease, sepsis, and multimorbidity. No published RCT has yet demonstrated senolytic clearance in humans. The only human data is a 2024 Mayo Clinic self-report survey, not a controlled trial in 536 long-COVID patients where 64% of fisetin users reported significant symptom improvement.

What it does

What Fisetin does in the body

Selective elimination of senescent cells (senolytics), reduction of the senescence-associated secretory phenotype (SASP) that drives chronic inflammation, and downstream potential benefits for age-related conditions driven by senescent cell accumulation. Fisetin is a flavonol found naturally in strawberries, apples, and persimmons that has been shown in multiple animal models to reduce senescent cell burden in tissues including liver, lung, and brain, extend median lifespan, and attenuate age-related cognitive and physical decline.

The evidence

What the research actually shows

Emerging and in active clinical trial phase. A 2018 Cell Metabolism study found fisetin was the most potent senolytic of ten natural compounds tested, reducing senescent cell burden and extending median lifespan in mice. A 2024 Mayo Clinic observational study in 536 long-COVID patients found 64% of the 44 patients who received fisetin reported significant reduction in fatigue, muscle pain, and orthostatic hypotension. Multiple phase 2 randomized controlled trials are currently underway: STOP-Sepsis (n=220 elderly sepsis patients, 20 mg/kg for 1 to 2 days), FIRST trial in peripheral artery disease (Northwestern University), and a pilot trial in healthy volunteers and multimorbidity patients. No published RCT has yet confirmed senolytic cell clearance in humans.

Food first

Getting Fisetin from food

Strawberries are the richest common food source of fisetin, containing approximately 160 micrograms per gram fresh weight. Apples, persimmons, kiwi, and onions also contain fisetin. The food-form quantities are far below senolytic protocol doses and provide fisetin as part of a broader polyphenol matrix with general antioxidant and anti-inflammatory dietary benefits.

What the guide adds

The part that is not on this page

Everything above is the assessment. What the guide adds for Fisetin is the protocol:

• Optimal Form
• Bioavailability
• Purity Red Flags
• Stack With / Avoid

147 entries across nine categories, every one graded against the clinical literature the same way.

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About the author

Who graded this

Daniel Edlund is a Le Cordon Bleu-trained private chef in Los Angeles, a certified personal trainer and strength coach, and an internationally licensed massage therapist. Thirty years of strength training and fifteen years cooking in private estate kitchens. He is the author of The Complete Supplement Guide, which grades 147 entries against the clinical literature, and of The EASY Way to Organic Cooking, first published in 2013.

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This page is information, not medical advice. Supplements interact with prescription medication and with each other, and the right answer depends on your own bloodwork and history. Talk to your doctor before starting anything, particularly if you are pregnant, nursing, managing a health condition, or already taking medication.

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All 147 entries, graded →